New Findings, Pathophysiology, and Antigen Analysis in Pollen-Food Allergy Syndrome

Akiko Yagami; Motohiro Ebisawa


Curr Opin Allergy Clin Immunol. 2019;19(3):218-223. 

In This Article

Pollen-food Allergy Syndrome Related to PR-10 Family

In many previous studies, sensitization to Bet v 1 has been shown to occur frequently in patients living in northern countries. Recently, in central and southern Italy, which are birch-free Mediterranean areas, Bet v 1 was also the most commonly observed PR-10 protein (74%) to show reactivity in patients.[27] In China, the majority of Chinese birch-allergic patients are IgE-sensitized to Bet v 1, as well as to the major apple allergen (Mal d 1) and soy bean allergen (Gly m 4).[28]

There is no question that Bet v 1 belonging to the PR-10 family is the major allergen involved in PFAS worldwide.