New Findings, Pathophysiology, and Antigen Analysis in Pollen-Food Allergy Syndrome

Akiko Yagami; Motohiro Ebisawa


Curr Opin Allergy Clin Immunol. 2019;19(3):218-223. 

In This Article

Pathogenesis-related Protein-10 Family

Pathogenesis-related proteins are induced by various types of pathogens, such as viruses, bacteria, and fungi.[23,24] Among pathogenesis-related families, Bet v 1 (17.5-kDa protein), belonging to the PR-10 family, is the main allergen present in pollen grains.[18] Many plant allergen proteins with sequence similarity to Bet v 1 have been identified,[17] such as Mal d 1 (apple), Pru ar 1f (apricot), Pru p 1 (peach), Api g 1 (celery), Gly m 4 (soy), Ara h 8 (peanut), Cor a 1 (hazelnut) and Cas s 1 (chestnut), and sola l 4 (tomato).[25] Sequence comparisons of some of these homologous allergens have shown significant sequence similarity to Bet v 1 with the food allergens: about 52.5% with Mal d 1, 57.8% with Pru av 1, 39.8% with Api g 1, 35.9% with Dau c 1, and about 55.0% and 56.6% with Pru p 1 and Pyr c 1, respectively. Cross-reactivity between Bet v 1 and Mal d 1 is also induced not only at the serologic level but also at the level of allergen-specific T-helper cells.[26] Eight cross-reacting T-cell epitopes have been indicated between the two allergens.