New Findings, Pathophysiology, and Antigen Analysis in Pollen-Food Allergy Syndrome

Akiko Yagami; Motohiro Ebisawa


Curr Opin Allergy Clin Immunol. 2019;19(3):218-223. 

In This Article

Management and Treatment of Pollen-food Allergy Syndrome

Patients should be provided with a management plan that includes avoidance advice and training in the administration of emergency medications, such as adrenaline (epinephrine) injection.

In previous publications, there reported that pollen allergen-specific immunotherapy (SIT) is beneficial for associated food allergies, primarily for patients with PFAS.[54,55] However, no standard treatments have been established and the main drawbacks of conventional allergen-SIT include systemic adverse reactions and the long duration of treatment. To address these problems, the development of transgenic rice seeds that accumulate recombinant hypoallergenic birch pollen allergen Bet v 1 and generate giant protein bodies has been promoted in Japan.[56] In 2017, Asero et al.[57] showed a case in which apple-induced oral allergy syndrome in a birch pollen-allergic patient disappeared following Omalizumab treatment.

Sensitization patterns to cross-reactive allergens may vary according to geographic location and eating habits. Establishing a standard SIT that corresponds to each PFAS is difficult. Progress in SIT is expected to be made in the future.