New Findings, Pathophysiology, and Antigen Analysis in Pollen-Food Allergy Syndrome

Akiko Yagami; Motohiro Ebisawa


Curr Opin Allergy Clin Immunol. 2019;19(3):218-223. 

In This Article

Gibberellin-regulated Protein in Other Fruit

Inomata et al.[50] showed the allergenicity of Japanese apricot GRP (JA GRP) and clarified the clinical characteristics of Japanese apricot allergy patients with GRP. All seven patients with Japanese apricot allergy were sensitized by JA GRP and ELISA inhibition assays using sera from Japanese apricot allergy patients indicated cross-reactivity between JA GRP and Pru p 7, suggesting that patients sensitized by GRP from Japanese apricot might possess cross-reactivity to peaches. Furthermore, they reported the allergenicity of orange GRP among patients with orange allergy.[51] They identified orange GRP as a potential cross-reactive allergen between citrus fruits and the Rosaceae family.

Sénéchal et al. showed that IgE cross-reactivity between peach and Italian cypress (Cupressus sempervirens, Cups) pollen is borne by members of the GRP family present in both allergenic sources, BP14 in cypress pollen and Pru p 7 in peach.[52] They also showed the clinical relevance of the cypress pollen allergenic GRP in PFAS and concluded that their results strongly suggested that, like Pru p 7, BP14 is a clinically relevant allergenic GRP from pollen.[53]

GRP is a newly identified allergen distributed in various plants related to vegetables and fruits, and will be investigated in various plants in the future.