New Findings, Pathophysiology, and Antigen Analysis in Pollen-Food Allergy Syndrome

Akiko Yagami; Motohiro Ebisawa


Curr Opin Allergy Clin Immunol. 2019;19(3):218-223. 

In This Article

Gibberellin-regulated Protein in Peach

Tuppo et al.[47] identified a peach allergen causing clinical picture similar to that of Pru p 3 (LTP). The allergen was registered as a new peach allergen (allergen name approved officially by the WHO and International Union of Immunological Societies, Pru p 7; peamaclein in 2013). They purified peamaclein from the fruit pulp for structural and immunological characterization. Hotta et al.[48] reported a case of food-dependent exercise-induced anaphylaxis because of peach with Pru p 7 sensitization. Furthermore, they showed a high prevalence of sensitization to native: nPru p 7 as a representative GRP (also known as peamaclein) in Japanese fruit allergy patients without sensitization to Bet v 1 homologs or profilin.[49] Among 13 nPru p 7-sensitized patients, causative foods were peaches (92.3%), apricots (61.5%), oranges (46.2%), and apples (30.8%). In eight patients (61.5%), exercise or aspirin intake enhanced the allergic reaction onset as cofactors. They concluded that GRP-sensitized patients may have allergies to multiple fruits and may show peculiar characteristics, such as facial swelling and cofactor dependence.