New Findings, Pathophysiology, and Antigen Analysis in Pollen-Food Allergy Syndrome

Akiko Yagami; Motohiro Ebisawa


Curr Opin Allergy Clin Immunol. 2019;19(3):218-223. 

In This Article

Abstract and Introduction


Purpose of review: PFAS shows various cross-reactivities with antigens because of the area in which the patient resides and dietary habits, and progress in component allergen analysis in recent years has clarified the pathogenesis. This review describes newly identified findings for antigens involved in PFAS.

Recent findings: We describe recent findings for PR-10 family, profilin and LTP, as known major antigens for PFAS. Microarrays of allergen components have significantly improved the ability to describe IgE profiles. In addition, we describe a new antigen, GRP, in the fruit pulp of recently identified fruit.

Summary: PFAS is a food allergy based on the cross-reactivity of pollen antigens and food antigens. Symptoms induced by sensitization differ depending on the specific antigen. The functions of each antigen are diverse, and even the same antigen can cause different symptoms. As analytical techniques progress, the findings will help to establish treatments, such as specific immunotherapy.


Thanks to improvements in techniques for antigen analysis, elucidation of the pathogenesis underlying pollen-food allergy syndrome (PFAS) has advanced markedly. In addition, differences exist in the antigens causing PFAS in each region, as revealed by epidemiological surveys and antigen analyses conducted in various geographic areas. This review overviews the main antigen underlying PFAS and discusses the topic of soy milk allergy related to Gly m 4 and gibberellin-regulated protein (GRP) as newly identified antigens.