Increase in Measles Cases — United States, January 1–April 26, 2019

Manisha Patel, MD; Adria D. Lee, MSPH; Susan B. Redd; Nakia S. Clemmons, MPH; Rebecca J. McNall, PhD; Amanda C. Cohn, MD; Paul A. Gastañaduy, MD


Morbidity and Mortality Weekly Report. 2019;68(17):402-404. 

In This Article

Abstract and Introduction


As of April 26, 2019, CDC had reported 704 cases of measles in the United States since the beginning of 2019, representing the largest number of cases reported in the country in a single year since 1994, when 963 cases occurred, and since measles was declared eliminated* in 2000.[1,2] Measles is a highly contagious, acute viral illness characterized by fever and a maculopapular rash; complications include pneumonia, encephalitis, and death. Among the 704 cases, 503 (71%) were in unvaccinated persons and 689 (98%) occurred in U.S. residents. Overall, 66 (9%) patients were hospitalized. Thirteen outbreaks have been reported in 2019, accounting for 663 cases, 94% of all reported cases. Six of the 13 outbreaks were associated with underimmunized close-knit communities and accounted for 88% of all cases. High 2-dose measles vaccination coverage in the United States has been critical to limiting transmission.[3] However, increased global measles activity poses a risk to U.S. elimination, particularly when unvaccinated travelers acquire measles abroad and return to communities with low vaccination rates.[4] Health care providers should ensure persons are up to date with measles, mumps, rubella (MMR) vaccine, including before international travel, and rapidly report all suspected cases of measles to public health authorities.

Measles cases are classified according to the Council of State and Territorial Epidemiologists' case definition for measles.[5] Cases are considered to be internationally imported if at least part of the exposure period (7–21 days before rash onset) occurred outside the United States and rash occurred within 21 days of entry into the United States, with no known exposure to measles in the United States during the exposure period. An outbreak of measles is defined as a chain of transmission of three or more cases linked in time and place and is determined by local and state health department investigations.

During January 1–April 26, 2019, a total of 704 measles cases were reported in 22 states (Figure 1); the highest number of weekly cases (87) were reported during the week ending March 23 (Figure 2). Median patient age was 5 years (interquartile range = 1 year to 18.5 years); 25 (4%) patients were aged <6 months, 68 (10%) 6–11 months, 76 (11%) 12–15 months, 167 (24%) 16 months–4 years, 203 (29%) 5–19 years, 138 (20%) 20–49 years, and 27 (4%) ≥50 years (Table). Among all measles patients, 503 (71%) were unvaccinated, 76 (11%) were vaccinated (received ≥1 measles, mumps, and rubella (MMR) vaccine), and the vaccination status of 125 (18%) was unknown. Overall, 66 (9%) patients were hospitalized, and 24 (3%) had pneumonia. No deaths or cases of encephalitis were reported to CDC.

Figure 1.

Number of reported measles cases (N = 704) — United States, January 1–April 26, 2019*
* Data are preliminary as of April 26, 2019.

Figure 2.

Number of reported measles cases (N = 704), by week of rash onset — United States, January 1–April 26, 2019*
* Data are preliminary as of April 26, 2019. Data for the week ending April 27 are for a partial week.

Of the 704 total cases, 663 (94%) were associated with outbreaks; 13 outbreaks have been reported in 2019. Outbreak-related cases have been reported in 12 states and New York City; multistate transmission was documented in four outbreaks. Six outbreaks were associated with underimmunized close-knit communities and accounted for 88% of all cases. New York state and New York City accounted for 474 (67%) of all cases reported in 2019 and have had ongoing transmission since October 2018.

Among the 704 cases, 689 (98%) occurred in U.S. residents. Forty-four cases were directly imported from other countries, including 34 (77%) that occurred in U.S. residents; 23 imports resulted in no known secondary cases. Among the 44 internationally imported measles cases, 40 (91%) were in unvaccinated persons or persons whose vaccination status was unknown; all 40 were age-eligible for vaccination, including two infant travelers aged 6–11 months. Source countries included Philippines (14 cases), Ukraine (8), Israel (5), Thailand (3), Vietnam (2), Germany (2), and one importation each from Algeria, France, India, Lithuania, Russia, and the United Kingdom. Four travelers went to multiple countries during their exposure period, including Italy/Singapore, Thailand/Cambodia, Ukraine/Israel, and Cambodia/Thailand/China/Singapore. Among 245 (35%) cases for which molecular sequencing was performed, B3 and D8 were the only genotypes identified, which were the most commonly detected genotypes worldwide in the past 12 months.

* Defined as absence of sustained measles transmission that is continuous for ≥12 months in a defined geographic area.
California, Connecticut, Georgia, Illinois, Maryland, Michigan, Missouri, New Jersey, New York, Oregon, Texas, and Washington.