Cannabinoids: Potential Role in Inflammatory and Neoplastic Skin Diseases

Rose Milando; Adam Friedman


Am J Clin Dermatol. 2019;20(2):167-180. 

In This Article


The endocannabinoid system in the skin is fully functioning and intricate; it is composed of multiple receptors, including CB1r/CB2r, TVRPs, PPARs, and GPR55, which are stimulated by numerous endogenous and exogenous cannabinoids. Various studies over the past two decades have brought to light the integral role of the endocannabinoid system in maintaining key aspects of skin homeostasis, including immune modulation, inflammation, cell proliferation, and differentiation. As such, the endocannabinoid system has been studied for its ability to regulate skin cancer and inflammatory diseases such as psoriasis, acne, dermatitis, and scleroderma. Further investigation into the specific influences of cannabinoid type, receptor, delivery method, and concentration will help further elucidate the intricacies of the endocannabinoid system in the skin. Doing so will provide the opportunity to expand our therapeutic arsenal for treating inflammatory and neoplastic diseases of the skin.