The Overlap of Irritable Bowel Syndrome and Noncoeliac Gluten Sensitivity

Anupam Rej; David S. Sanders


Curr Opin Gastroenterol. 2019;35(3):199-205. 

In This Article


There appears to be significant overlap between NCGS and IBS. It is likely that a subset of patients presenting with IBS symptoms actually have NCGS, best diagnosed currently using the Salerno experts' criteria, although not without its limitations. Whilst individuals with NCGS note that gluten induces symptoms in comparison to IBS, it appears that individuals with IBS may benefit from a GFD also. There is currently debate with regards to the component of wheat is responsible for symptom generation, with further research required to delineate the pathophysiology of both NCGS and IBS. The development of accurate biomarkers in the future may help delineate NCGS and IBS further.