Chronic Obstructive Pulmonary Disease Prevalence Among Adults Who Have Never Smoked, by Industry and Occupation — United States, 2013–2017

Girija Syamlal, MBBS; Brent Doney, PhD; Jacek M. Mazurek, MD

Disclosures

Morbidity and Mortality Weekly Report. 2019;68(13):303-307. 

In This Article

Discussion

An estimated 24% of U.S adults with COPD have never smoked.[3,4] Among persons who never smoked, an estimated 26%–53% of COPD can be attributed to occupational exposures.[4–6] Previous studies have shown that occupational exposures to dust and toxins, as well as biologic and social differences, and genetic factors were associated with increased risk for COPD among persons who never smoked.[1,3,5,7] Therefore, identifying occupational risk factors is needed for preventing and reducing COPD among workers. This study, which provides industry- and occupation-specific COPD prevalence estimates among 106 million persons who never smoked and were employed any time in the past 12 months, found that two thirds of those with COPD were women. Women who had never smoked had higher COPD prevalences than did men regardless of their sociodemographic characteristics. Within-group variations were observed among sex, race, and ethnicity, with the highest prevalences among non-Hispanic black women and non-Hispanic white men.

National surveys have shown that exposure to vapors, gas, dust, fumes, grain dust, organic dust, inorganic dust, ammonia, hydrogen sulfide, diesel exhaust, environmental tobacco smoke, and chemicals increases the risk for COPD morbidity and mortality among persons who have never smoked.[4–6] For example, exposure to coal mine dust or respirable crystalline silica among workers in the mining industry has been associated with COPD and other pulmonary diseases. In this study, office and administrative support workers (including secretaries, administrative and dental assistants, and clerks), protective service workers, and information industry workers (including publishing, telecommunications, broadcasting, and data processing workers) had the highest COPD prevalences. Workers in these industries can be exposed to organic and inorganic dusts, isocyanates, irritant gases, paper dust and fumes from photocopiers, chemicals, oil-based ink, paints, glues, isocyanates, toxic metals, and solvents, all of which are known respiratory irritants and have been associated with bronchitis, emphysema, and COPD.**,†† In addition, workplace exposures to environmental tobacco smoke can be associated with COPD.[8]

In this report, although the pattern of responses to all three COPD-related questions among those who ever smoked and those who never smoked was similar (i.e., highest proportions with COPD were among those who were diagnosed with chronic bronchitis), chronic bronchitis was 19 times more frequently reported than emphysema among those who never smoked, compared with 3.5 times among those who ever smoked. These results are similar to those previously reported that a substantial proportion of COPD among the nonsmoker population might be explained by chronic bronchitis.[9]

The findings in this report are subject to at least five limitations. First, information on COPD was self-reported and not validated by medical records review or pulmonary function tests. Second, no work history, secondhand smoke exposure, or workplace exposure information was available to assess associations with COPD. Third, only workers employed at some time in the past 12 months were included in this study. Those with severe COPD might have left the workforce, and COPD prevalence might be underestimated. Fourth, despite combining data for multiple years, small sample sizes in certain groups resulted in unreliable estimates. Finally, the survey collected information on any physician office visits or ED visits in the past 12 months and lost workdays because of any illness or injury, and these visits might not be associated with COPD.

The findings of high COPD prevalences among workers who never smoked corroborates findings that occupational exposures, in addition to smoking, might be associated with development of COPD. Higher COPD prevalences in certain industries and occupations underscore the importance of continued surveillance, identification of potential workplace exposures, collection of detailed occupational history, performance of pulmonary function testing, and assessment of environmental tobacco smoke exposure for early diagnosis and treatment of COPD among workers.[10] Efforts to reduce adverse workplace exposures (including exposure to dust, vapors, fumes, chemicals, and indoor and outdoor air pollutants) and promote research to characterize the many contributing risk factors in COPD are needed to reduce the prevalence of COPD.§§

Comments

3090D553-9492-4563-8681-AD288FA52ACE

processing....