Effect of Ketofol Versus Propofol as an Induction Agent on Ease of Laryngeal Mask Airway Insertion Conditions and Hemodynamic Stability in Pediatrics

An Observational Prospective Cohort Study

Bacha Aberra; Adugna Aregawi; Girmay Teklay; Hagos Tasew

Disclosures

BMC Anesthesiol. 2019;19(41) 

In This Article

Comparison of Hemodynamic Characteristics

Patients in both groups were comparable with respect to preoperative baseline hemodynamic conditions. The mean arterial pressure difference between the group is not significantly different before induction (p-value = 0.263; is insignificant). With the induction of anesthesia, a significant drop in mean arterial blood pressure was observed in propofol group from baseline while in the ketofol group, there was a rise in mean arterial pressure at all measurement times (P < 0.001) [Figure 1]. Maximum mean blood pressure was 81.5 ± 11.02 mmHg with a ketofol group seen immediately after induction [Table 5].

Figure 1.

Changes in mean arterial pressure between ketofol and propofol group. NB: t, baseline, t1, immediately following induction of anesthesia, t2, immediately after LMA placement, t3, t4, and t5,1,2 and 3 min after LMA placement

Preoperatively there was no statistically significant difference (p-value> 0.05) between the heart rate of both groups. P values at all levels after induction were < 0.05 and statistically significant. With the induction of anesthesia, a significant rise in heart rate was observed in the ketofol group from baseline while in propofol group, there was a drop in heart rate at all measurement times (P < 0.05) [Figure 2]. The increment in heart rate was seen immediately after induction compared with baseline. Maximum heart rate was 118.55 ± 24.86 beat/min with a ketofol group seen immediately after LMA insertion. Minimum heart rate (99.62 ± 25.071) was seen in propofol group 3 min after LMA insertion [Table 6].

Figure 2.

Changes in heart rate between ketofol and propofol group. NB: t, baseline, t1, immediately following induction of anesthesia, t2, immediately after LMA placement, t3, t4, and t5,1,2 and 3 min after LMA placement

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