Effect of Ketofol Versus Propofol as an Induction Agent on Ease of Laryngeal Mask Airway Insertion Conditions and Hemodynamic Stability in Pediatrics

An Observational Prospective Cohort Study

Bacha Aberra; Adugna Aregawi; Girmay Teklay; Hagos Tasew


BMC Anesthesiol. 2019;19(41) 

In This Article

Comparison of Ease of Insertions Conditions

In 12 (20%) of the propofol group patients, additional 0.5–1 mg/kg) propofol was required as compared to nine (15%) of those in the ketofol group. However, no significant difference was noted between the two groups (p = 0.631). The time from the LMA placement to the return of spontaneous ventilation was significantly longer in propofol group (240 s [range = 60–390 s]) compared with a ketofol group (180 s [range = 30–380 s]) (p = 0.005), expressed in median and range respectively. The LMA was inserted successfully and positioned correctly on the first attempt in 95% of patients receiving ketofol compared with 96.67% in patients receiving propofol [Table 3].

LMA insertion summed score was nearly similar between the two group, which were statistically insignificant (p = 0.511). No patient developed laryngospasm in the ketofol group while 2 patients (3.33%) developed partial laryngospasm in propofol group but not statistically significant (p = 0.154) [Table 4].