Adverse Effects of Topical Photodynamic Therapy

A Consensus Review and Approach to Management

S.H. Ibbotson; T.H. Wong; C.A. Morton; N.J. Collier; A. Haylett; K.E. McKenna; R. Mallipeddi; H. Moseley; L.E. Rhodes; D.C. Seukeran; K.A. Ward; M.F. Mohd Mustapa; L.S. Exton


The British Journal of Dermatology. 2019;180(4):715-729. 

In This Article

Safety Aspects of Topical Photodynamic Therapy

Contraindications to PDT include a history of porphyria and allergy/photoallergy to the photosensitizer prodrug preparations or the active ingredients.[144,146,149] Most PDT is carried out using red light, which is not phototoxic to the retina. However, blue light can pose a hazard to the retina, potentially causing irreversible damage to the photosensitive neurotransmitters in the macula.[208] Wearing goggles, for both patient and staff, is recommended to limit the transmission of high-intensity light and to avoid discomfort and disturbance of colour perception. Following topical PDT, localized photosensitivity can remain for up to 48 h.[125,209]