Candida Bloodstream Infections Among Persons Who Inject Drugs — Denver Metropolitan Area, Colorado, 2017–2018

Devra M. Barter, MS; Helen L. Johnston, MPH; Sabrina R. Williams, MPH; Sharon V. Tsay, MD; Snigdha Vallabhaneni, MD; Wendy M. Bamberg, MD

Disclosures

Morbidity and Mortality Weekly Report. 2019;68(12):285-288. 

In This Article

Abstract and Introduction

Introduction

Candidemia, a bloodstream infection caused by Candida species, is typically considered a health care–associated infection, with known risk factors including the presence of a central venous catheter, receipt of total parenteral nutrition or broad-spectrum antibiotics, recent abdominal surgery, admission to an intensive care unit, and prolonged hospitalization.[1,2] Injection drug use (IDU) is not a common risk factor for candidemia; however, in the context of the ongoing opioid epidemic and corresponding IDU increases, IDU has been reported as an increasingly common condition associated with candidemia[3] and methicillin-resistant Staphylococcus aureus bacteremia.[4] Little is known about the epidemiology of candidemia among persons who inject drugs. The Colorado Department of Public Health and Environment (CDPHE) conducts population-based surveillance for candidemia in the five-county Denver metropolitan area, encompassing 2.7 million persons, through CDC's Emerging Infections Program (EIP). As part of candidemia surveillance, CDPHE collected demographic, clinical, and IDU behavior information for persons with Candida-positive blood cultures during May 2017–August 2018. Among 203 candidemia cases reported, 23 (11%) occurred in 22 patients with a history of IDU in the year preceding their candidemia episode. Ten (43%) of the 23 cases were considered community-onset infections, and four (17%) cases were considered community-onset infections with recent health care exposures. Seven (32%) of the 22 patients had disseminated candidiasis with end-organ dysfunctions; four (18%) died during their hospitalization. In-hospital IDU was reported among six (27%) patients, revealing that IDU can be a risk factor in the hospital setting as well as in the community. In addition to community interventions, opportunities to intervene during health care encounters to decrease IDU and unsafe injection practices might prevent infections, including candidemia, among persons who inject drugs.

Candidemia surveillance in the five-county Denver metropolitan area began in May 2017. Because candidemia is a reportable condition in the Denver metropolitan area, all surveillance area laboratories report Candida-positive blood cultures to CDPHE. As part of EIP surveillance, a case is defined as a blood culture positive for Candida spp. in a surveillance area resident; a recurrent case is defined as a new Candida-positive blood culture >30 days after the initial positive blood culture in the same patient. Cases were classified by patient epidemiologic exposures. Community-onset infections were defined as Candida-positive blood culture collected <3 days after hospital admission with no previous health care exposures (i.e., overnight hospitalizations, surgeries, long-term care, or long term acute care admissions in the previous 90 days and no central lines in place in the 2 days prior to culture collection). Health care–associated, community-onset infections were defined as a Candida-positive blood culture collected <3 days after hospital admission with previous health care exposures in the 90 days before the culture collection date. Hospital-onset infections were defined as blood cultures collected ≥3 days into the patient's hospitalization. Medical record reviews were performed to gather demographic and clinical information, including history of IDU, for all patients using a standardized case report form.

During the first 6 months of the surveillance program, CDPHE observed that approximately one in 10 cases of candidemia occurred in patients who had a documented history of IDU, and the majority of their Candida-positive blood cultures were collected on the day of hospital admission or shortly thereafter. This finding was unexpected given that candidemia typically occurs in severely ill, hospitalized patients.[1,2] CDPHE and CDC conducted an epidemiologic investigation to describe candidemia among persons who inject drugs and identify potential interventions for prevention. For each case occurring in a person with documented IDU, medical records were reviewed to collect information on health care exposures, evidence of disseminated infections, coinfections, and drug use and associated practices before the Candida-positive cultures.

Among 203 candidemia cases reported during May 2017–August 2018, 23 (11%) were identified in 22 patients with IDU in the past year; one patient had recurrent candidemia. Among these 22 patients, the average age was 37 years (range = 21–59 years), and 14 (64%) were women (Table). Eighteen (82%) of the patients were white, and four (18%) were Hispanic or Latino. Eleven (50%) patients had experienced homelessness or lived in transitional housing before the candidemia episode. Among the 22 candidemia patients with IDU, 10 (45%) had hepatitis C infection, including one who also had chronic hepatitis B infection and one who also had human immunodeficiency virus (HIV) infection. Other comorbidities included chronic lung disease; neurologic conditions such as seizures, epilepsy, or neuropathy; diabetes; alcohol abuse; and smoking tobacco during the preceding year.

Three patients left the hospital against medical advice, possibly without completing treatment for candidemia. Three additional patients had left against medical advice from at least one other medical encounter in the 6 months before their candidemia episode. Four (18%) patients died in the hospital 1–17 days after the Candida-positive blood culture, although whether candidemia was the direct cause of death was unknown.

Among the 23 infections in these 22 patients, the most common Candida species identified were Candida glabrata, Candida albicans, and Candida parapsilosis (Table). Ten (43%) of the 23 cases were identified as community-onset infections. Four (17%) cases were identified within 1 day of the patient's hospital admission or during a previous emergency department (ED) visit or hospitalization, after which the patient returned for treatment; these patients also had other health care exposures and were classified as health care–associated, community-onset infections. Nine (39%) cases were classified as hospital-onset infections. Among the nine patients with hospital-onset candidemia, the median interval from hospital admission to collection of the Candida-positive blood culture was 17 days (range = 4–107 days). Among all 23 candidemia cases, the median length of the candidemia-associated hospitalization was 10 days (range = 1–139 days).

In the 6 months before developing candidemia, the 22 patients had a mean of three previous inpatient or ED visits (range = 0–10). Including the admission for candidemia, the most common reasons for admission or ED visit were conditions related to drug use (i.e., dependence or withdrawal); nonspecific pain; mental or behavioral disorders; and infections and associated complications, including bacteremia, osteomyelitis, and sepsis.

Fifteen (68%) of the 22 patients had a blood culture yielding another organism (most commonly Staphylococcus aureus) either during the candidemia hospitalization or in the 6 months preceding the candidemia episode. In 10 (45%) patients, at least one other organism was identified in the same blood culture set as the one that yielded Candida spp. These included Staphylococcus aureus,coagulase negative Staphylococcus, Stenotrophomonas maltophilia, Pseudomonas fluorescens, Serratia marcescens, Enterobacter asburiae, Comamonas acidovorans, Pantoea spp., viridans Streptococcus, and Mucorales spp. Seven (32%) patients had disseminated candidiasis with end-organ dysfunctions, including endophthalmitis (one), septic emboli (one), osteomyelitis (three), and abscesses of the pelvis, psoas muscle, and upper mediastinum (three).

Drugs documented in the medical record or identified in urine testing in the 6 months before the candidemia episode included opioids (18 patients; 82%), methamphetamines (16; 73%), cannabinoids (seven; 32%), cocaine (six; 27%), benzodiazepines (four; 18%), ecstasy (MDMA) (one), and barbiturates (one). Two patients (9%) experienced "cotton fever," an illness characterized by rapid fever onset immediately following the injection of drugs filtered through cotton,[5] in the 6 months before the candidemia hospitalization; four patients (18%) were reported to have engaged in unsafe injection practices, including using old syringes, cotton, filters, and dirty needles.

Six (27%) patients were observed injecting or attempting to inject drugs, including illicit drugs and pain medications that were not prescribed to them, while hospitalized. In addition, illicit drugs and drug paraphernalia, including syringes, spoons, and lighters, were found in four of these six patients' rooms.

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