Invasive and Non-Invasive Diagnostic Approaches for Microbiological Diagnosis of Hospital-Acquired Pneumonia

Otavio T. Ranzani; Tarek Senussi; Francesco Idone; Adrian Ceccato; Gianluigi Li Bassi; Miquel Ferrer; Antoni Torres

Disclosures

Crit Care. 2019;23(51) 

In This Article

Abstract and Introduction

Abstract

Background: Data on the methods used for microbiological diagnosis of hospital-acquired pneumonia (HAP) are mainly extrapolated from ventilator-associated pneumonia. HAP poses additional challenges for respiratory sampling, and the utility of sputum or distal sampling in HAP has not been comprehensively evaluated, particularly in HAP admitted to the ICU.

Methods: We analyzed 200 patients with HAP from six ICUs in a teaching hospital in Barcelona, Spain. The respiratory sampling methods used were divided into non-invasive [sputum and endotracheal aspirate (EAT)] and invasive [fiberoptic-bronchoscopy aspirate (FBAS), and bronchoalveolar lavage (BAL)].

Results: A median of three diagnostic methods were applied [range 2–4]. At least one respiratory sampling method was applied in 93% of patients, and two or more were applied in 40%. Microbiological diagnosis was achieved in 99 (50%) patients, 69 (70%) by only one method (42% FBAS, 23% EAT, 15% sputum, 9% BAL, 7% blood culture, and 4% urinary antigen). Seventy-eight (39%) patients underwent a fiberoptic-bronchoscopy when not receiving mechanical ventilation. Higher rates of microbiological diagnosis were observed in the invasive group (56 vs. 39%, p = 0.018). Patients with microbiological diagnosis more frequently presented changes in their empirical antibiotic scheme, mainly de-escalation.

Conclusions: A comprehensive approach might be undertaken for microbiological diagnosis in critically ill nonventilated HAP. Sputum sampling determined one third of microbiological diagnosis in HAP patients who were not subsequently intubated. Invasive methods were associated with higher rates of microbiological diagnosis.

Introduction

Hospital-acquired pneumonia (HAP) is a frequent event during an intensive care unit (ICU) stay and is characterized by a pneumonia acquired during hospitalization, in patients without invasive mechanical ventilation.[1–3] Despite improved prevention measures, antimicrobial therapy, and supportive care, it remains an important cause of morbidity and mortality.[1–3] HAP is the leading cause of death among hospital-acquired infections, with estimates of its associated mortality ranging from 20 to 50%.[2,4–6]

Microbiological diagnosis is fundamental for guiding HAP treatment, allowing a targeted, effective antibiotic choice, and reducing the associated impact of ineffective empiric antibiotic regimens or the unnecessary use of broad-spectrum antibiotics.[1] Yet the current understanding of HAP pathogens is based mainly on data derived from ventilator-associated pneumonia (VAP).[7–15] Although some studies have reported the pathogens in HAP that occur outside the ICU,[16–18] there is no systematic description of the diagnostic approaches that should be used to efficiently obtain an microbiological diagnosis in HAP, mainly when critically ill.[1]

In comparison with VAP, HAP poses additional challenges for respiratory sampling and, thus, for obtaining microbiological diagnosis. The utility of sputum cultures or distal sampling for HAP has not been comprehensively evaluated.[1] The recent guidelines for HAP/VAP recognized that for some patients, whom non-invasively sampling is not possible, invasive sampling is an option;[1,3] however, the literature is scarce to support one method over the other in HAP. In this study, we aimed to describe the diagnostic approaches used in a cohort of HAP acquired during an ICU stay and their associated clinical impact.

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