The Current Role of Circulating Biomarkers in Non-Muscle Invasive Bladder Cancer

Michael Rink; Heidi Schwarzenbach; Malte W. Vetterlein; Sabine Riethdorf; Armin Soave; on behalf of the EAU Young Academic Urologists—Urothelial Cancer Working party


Transl Androl Urol. 2019;8(1):61-75. 

In This Article


We performed a non-systematic PubMed/Medline literature search to identify original articles, review articles, editorials and comments regarding CTC and ctDNA in association with NMIBC. Searches were limited to the English language. Key words included urothelial cancer or carcinoma, NMIBC, CTC, ctDNA, circulating cell-free DNA, plasma DNA, serum DNA, transurethral resection of the bladder, TURBT, instillation therapy, disease recurrence, progression and survival. The literature search was timely unlimited, but our article focuses on the most significant findings from the past ten years. Articles with the highest level of evidence were selected and reviewed.