A Systematic Review of Randomized Controlled Trials Investigating the Efficacy and Safety of Testosterone Therapy for Female Sexual Dysfunction in Postmenopausal Women

Channa N. Jayasena; Fatima M. Alkaabi; Curtis S. Liebers; Thomas Handley; Stephen Franks; Waljit S. Dhillo


Clin Endocrinol. 2019;90(3):391-414. 

In This Article

Materials and Methods

Search and Selection

A search of the electronic databases CENTRAL, EMBASE, MEDLINE and PubMed was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement during July 2018[10] (See Table S1). All studies identified using search terms up until July 2018 were considered for inclusion to the study. Databases were searched using the following terms: "female OR females OR women OR woman," AND "postmenopausal OR postmenopausal OR postmenopause OR postmenopause OR perimenopausal OR peri-menopausal OR perimenopause OR peri-menopause OR climacteric" AND "testosterone" AND "placebo OR placebos OR random OR randomised OR randomized OR randomly OR randomly allocated." Identified studies were excluded if the abstracts were not in the English language, or included purely pharmacokinetic outcomes. For studies to be included, subjects were required to be perimenopausal or postmenopausal women presenting with symptoms of sexual dysfunction, dyslipidaemia, impaired memory, decreased bone mineral density or breast symptoms. One study was excluded because all subjects had rheumatoid arthritis.[11]

Data Extraction

Study titles and abstracts were initially screened before full-text review was completed in duplicate by two study investigators (CSL and CNJ). Discrepancies were dealt with by consensus. A total of 69 studies fulfilled the criteria for inclusion to this systematic review (Figure 1). Data identified for all studies were as follows: date of publication; intervention administered; blinding; randomization; treatment duration; allocation; route of administration and treatment dosage; number of subject participants; design of the study, study references and source of funding.

Figure 1.

PRISMA chart summarising search strategy for the systematic review