Acute Migraine Therapy During Pregnancy: A Primer

Anna Pace, MD


February 15, 2019

Editorial Collaboration

Medscape &


A 32-year-old woman presents with a complaint of migraines. She has about four to five headache days a month, and her headaches are characterized by a unilateral throbbing sensation with severe nausea and photophobia, occasionally osmophobia. She has been using either sumatriptan or naproxen as an abortive regimen, occasionally both together, with good relief. The headaches are worse around her menses, and those headaches typically do not respond well to the sumatriptan/naproxen combination. Recently married, she wants to try to conceive within the next few months and is interested to learn which medications are safe to use during pregnancy.


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