Relation Between Hysterectomy, Oophorectomy and the Risk of Incident Differentiated Thyroid Cancer

The E3N Cohort

Agathe Guenego; Sylvie Mesrine; Laureen Dartois; Laurence Leenhardt; Françoise Clavel-Chapelon; Marina Kvaskoff; Marie-Christine Boutron-Ruault; Fabrice Bonnet

Disclosures

Clin Endocrinol. 2019;90(2):360-368. 

In This Article

Conclusion

Our findings showed that hysterectomy or a history of fibroids were associated with a twofold increased risk of differentiated thyroid cancer (micro- and macro-carcinomas) in mostly postmenopausal women. This relation might be explained by common signalling pathways regulated by oestrogen, progesterone or TSH/thyroid hormones. Further studies are needed to delineate the underlying molecular mechanisms or pathways.

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3090D553-9492-4563-8681-AD288FA52ACE

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