Burdens of Invasive Methicillin-Susceptible and Methicillin-Resistant Staphylococcus Aureus Disease, Minnesota, USA

Mackenzie Koeck; Kathryn Como-Sabetti; Dave Boxrud; Ginette Dobbins; Anita Glennen; Melissa Anacker; Selina Jawahir; Isaac See; Ruth Lynfield


Emerging Infectious Diseases. 2019;25(1):171-174. 

In This Article

Abstract and Introduction


During August 1, 2014–July 31, 2015, in 2 counties in Minnesota, USA, incidence of invasive methicillin-susceptible Staphylococcus aureus (MSSA) (27.1 cases/100,000 persons) was twice that of invasive methicillin-resistant S. aureus (13.1 cases/100,000 persons). MSSA isolates were more genetically diverse and susceptible to more antimicrobial drugs than methicillin-resistant S. aureus isolates.


Methicillin-resistant Staphylococcus aureus (MRSA) infections were first reported in the 1960s in healthcare facilities.[1] Risk factors included recent hospitalization, surgery, dialysis, having a central venous catheter or other invasive medical device, chronic wounds, residence in long-term care facilities or prisons, injection drug use, and exposure to antimicrobial drugs.[2] In the 1990s, MRSA infections caused by genetically distinct strains were observed among healthy persons in the community.[3]

Although S. aureus has long been recognized as a major human pathogen, epidemiologic studies and infection prevention precautions in recent decades have largely focused on MRSA. We compared epidemiologic, microbiologic, and molecular characteristics of invasive methicillin-susceptible S. aureus(MSSA) infections with those of invasive MRSA infections.