Circulating Serotonin Levels in COPD Patients

A Pilot Study

Pietro Pirina; Elisabetta Zinellu; Panagiotis Paliogiannis; Alessandro G. Fois; Viviana Marras; Salvatore Sotgia; Ciriaco Carru; Angelo Zinellu


BMC Pulm Med. 2018;18(167) 

In This Article


Our study confirms literature data showing an involvement of serotonin in the pathogenesis of COPD, demonstrating a statistically significant increase of circulating serotonin levels in an early phase of the disease, and a relation with the worsening of the airway obstruction. Given the need of biomarkers useful to detect and monitor COPD and its response to treatments, this seems to be a promising result that need to be further investigated.