Sex Hormones and Their Influence on Chronic Kidney Disease

José Manuel Valdivielso; Conxita Jacobs-Cachá; María José Soler

Disclosures

Curr Opin Nephrol Hypertens. 2019;28(1):1-9. 

In This Article

Conclusion

In summary, male gender is associated with faster CKD progression to ESRD when compared to females. Sex hormones and its receptors play a critical role in the progression of the damaged kidney through different pathophysiological pathways such as the RAS system, oxidative stress, and fibrosis. Strategies aimed to enhance female sex hormones and decrease male sex hormones may exert a future positive effect on the damaged kidney.

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