Vomiting in Infancy: Is It FPIES?

Elizabeth Feuille, MD; Anna H. Nowak-Wegrzyn, MD, PhD


January 02, 2019

What Is FPIES?

Food protein-induced enterocolitis syndrome (FPIES) is an uncommon and poorly understood immunologically mediated gastrointestinal food hypersensitivity that most often presents in infancy.[1] Cow's milk and soy proteins are the most common food triggers; other foods that may cause FPIES include a wide array of solid foods, including grains, vegetables, fruits, and poultry. The incidence data for FPIES are limited, and estimates of infants affected vary from 1.5 to 30 per 10,000.[2,3] Although FPIES is more prevalent than previously thought, diagnostic delay is still common,[4] and clinician awareness of FPIES appears to be low.[5]


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