Progression-Free Survival at 24 Months (PFS24) and Subsequent Outcome for Patients With Diffuse Large B-cell Lymphoma (DLBCL) Enrolled on Randomized Clinical Trials

M. J. Maurer; T. M. Habermann; Q. Shi; N. Schmitz; D. Cunningham; M. Pfreundschuh; J. F. Seymour; U. Jaeger; C. Haioun; H. Tilly; H. Ghesquieres; F. Merli; M. Ziepert; R. Herbrecht; J. Flament; T. Fu; C. R. Flowers; B. Coiffier

Disclosures

Ann Oncol. 2018;29(8):1822-1827. 

In This Article

Abstract and Introduction

Abstract

Background: Patients with diffuse large B-cell lymphoma treated with first-line anthracycline-based immunochemotherapy and remaining in remission at 2 years have excellent outcomes. This study assessed overall survival (OS) stratified by progression-free survival (PFS) at 24 months (PFS24) using individual patient data from patients with DLBCL enrolled in multi-center, international randomized clinical trials as part of the Surrogate Endpoint for Aggressive Lymphoma (SEAL) Collaboration.

Patients and methods: PFS24 was defined as being alive and PFS24 after study entry. OS from PFS24 was defined as time from identified PFS24 status until death due to any cause. OS was compared with each patient's age-, sex-, and country-matched general population using expected survival and standardized mortality ratios (SMRs).

Results: A total of 5853 patients enrolled in trials in the SEAL database received rituximab as part of induction therapy and were included in this analysis. The median age was 62 years (range 18–92), and 56% were greater than 60 years of age. At a median follow-up of 4.4 years, 1337 patients (23%) had disease progression, 1489 (25%) had died, and 5101 had sufficient follow-up to evaluate PFS24. A total of 1423 assessable patients failed to achieve PFS24 with a median OS of 7.2 months (95% CI 6.8–8.1) after progression; 5-year OS after progression was 19% and SMR was 32.1 (95% CI 30.0–34.4). A total of 3678 patients achieved PFS24; SMR after achieving PFS24 was 1.22 (95% CI 1.09–1.37). The observed OS versus expected OS at 3, 5, and 7 years after achieving PFS24 was 93.1% versus 94.4%, 87.6% versus 89.5%, and 80.0% versus 83.7%, respectively.

Conclusion: Patients treated with rituximab containing anthracycline-based immunochemotherapy on clinical trials who are alive without progression at 24 months from the onset of initial therapy have excellent outcomes with survival that is marginally lower but clinically indistinguishable from the age-, sex-, and country-matched background population for 7 years after achieving PFS24.

Introduction

Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma in the USA[1] and Europe.[2] Outcomes have improved with the introduction of immunochemotherapy for DLBCL[3–5] with the majority of patients being cured by front-line therapy. Patients with DLBCL who receive first-line anthracycline-based immunochemotherapy who have not had an event (relapse, re-treatment, or death), at 24 months from diagnosis (EFS24) have excellent outcomes with an overall survival (OS) that is similar to the age- and sex-matched general populations in patient cohorts from observational studies from the USA, France, and Denmark.[6,7]

There is a need for early end points to assess approaches from randomized clinical trials that would not necessitate waiting for OS results in newly diagnosed DLBCL. The Surrogate Endpoint for Aggressive Lymphoma (SEAL) group was assembled to compile a large meta-database as previously described.[8] Progression-free survival (PFS) in patients who had defined evaluation and scan point may offer a more accurate assessment of the time of relapse compared with registry or population-based cohorts. To evaluate the robustness and generalizability of a 24-month end point in the clinical trial setting, this study assessed OS stratified by PFS at 24 months (PFS24) using individual patient data from patients with newly diagnosed DLBCL enrolled in 14 different multi-center, international randomized clinical trials.

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