Vitamin D Deficiency and Supplementation in Critical Illness

The Known Knowns and Known Unknowns

Priya Nair; Balasubramaniam Venkatesh; Jacqueline R Center


Crit Care. 2018;22(276) 

In This Article


The putative pleiotropic benefits of vitamin D supplementation warrant further in-depth exploration with adequately powered multi-centre randomised trials.

This would require reliable assessment of baseline vitamin D status and metabolites with standardised assays. The most effective and safe method of supplementation with respect to preparation, dose, route and frequency of administration are all important considerations. In addition, an appropriate population should be identified who are most likely to benefit from supplementation and stratification of the population or a priori subgroups may need to be considered. Finally, relevant patient-centred primary and secondary endpoints will need to be selected.