POEMs: Patient-Oriented Evidence That Matters

Long-Acting Muscarinic Antagonists Plus Inhaled Steroids are Equivalent to Long-Acting Beta Agonists Plus Inhaled Steroids

David Slawson, MD


Am Fam Physician. 2018;98(8) 

In This Article

Bottom Line

Long-acting muscarinic antagonists added to inhaled corticosteroids are a superior treatment to placebo for improving asthma control in adults and children 12 years or older. Long-acting muscarinic antagonist add-on therapy is not superior to long-acting beta agonist (LABA) add-on therapy. The addition of long-acting muscarinic antagonists in patients already receiving LABA plus inhaled corticosteroids (triple therapy) does not further improve asthma control. (Level of Evidence = 1a)