Review Article

The Relationship Between Obesity, Bariatric Surgery, and Inflammatory Bowel Disease

Fiorella Cañete; Míriam Mañosa; Ariadna Clos; Eduard Cabré; Eugeni Domènech


Aliment Pharmacol Ther. 2018;48(8):807-816. 

In This Article


Bibliographical searches were performed in the MEDLINE electronic database up to January 2018 looking for the following key words (all fields): ("Inflammatory bowel disease" OR "Crohn's disease" OR "ulcerative colitis") AND ("obesity" OR "morbid obesity" OR "morbidly obese patient") AND ("Bariatric Surgery" OR "sleeve gastrectomy" OR "gastric bypass surgery"). Two different outcomes were considered in this review: (a) the development of IBD after bariatric surgery and (b) the safety of bariatric surgery in IBD patients. The references from the articles selected for the study were also examined in search of articles meeting the inclusion criteria according to the outcomes. Only articles published in English, French, German or Spanish were included. In addition, a search with the key words "bariatric" and "bariatric surgery" was performed among all the abstracts of the European Crohns and Colitis Organization Congress, the United European Gastroenterology Week, and the Digestive Disease Week from 2013 to 2018. For cases of the de novo development of IBD after bariatric surgery, the following variables were extracted: age, gender, preoperative BMI, type of bariatric surgery, time of onset after surgery and location and phenotype of IBD. Studies and case reports describing the performance of bariatric surgery in IBD patients were also reviewed and the following variables were recorded: age, IBD phenotype, IBD duration, comorbidities, type of bariatric procedure, follow-up, treatment of IBD and perioperative complications. A narrative synthesis was used to describe and compare the case series included.