The Global Burden of Sepsis: Barriers and Potential Solutions

HIV human immunodeficiency virus, LMIC low and middle-income country

ICU intensive care unit, LMIC low and middle-income country

Authors and Disclosures

Kristina E. Rudd^1,2,3*, Niranjan Kissoon⁴, Direk Limmathurotsakul^5,6, Sotharith Bory⁷, Birungi Mutahunga⁸, Christopher W. Seymour⁹, Derek C. Angus¹⁰ and T. Eoin West<sup>1,2,11

1</sup>International Respiratory and Severe Illness Center, University of Washington, Seattle, WA, USA. ²Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA. ³Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 3550 Terrace St., Scaife Hall, #639, Pittsburgh, PA, USA. ⁴Division of Critical Care, Department of Pediatrics, University of British Columbia, British Columbia Children's Hospital, Vancouver, BC, Canada. ⁵Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand. ⁶Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. ⁷Division of Infectious Diseases, Department of Medicine, Calmette Hospital, Phnom Penh, Cambodia. ⁸Bwindi Community Hospital, Kanungu, Uganda. ⁹Departments of Critical Care and Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. ¹⁰Department of Critical Care Medicine, University of Pittsburgh School of Medicine and UPMC Health System, Pittsburgh, PA, USA. ¹¹Department of Global Health, University of Washington, Seattle, WA, USA.

*Correspondence
ruddk@pitt.edu

Authors' contributions
KER contributed to the concept and design, critically reviewed the literature, prepared the figures and tables, and prepared the initial draft of the paper. NK, DL, SB, BM, CWS, and DCA reviewed the concepts, contributed to design of the work, and critically revised the paper. TEW conceptualized the review, critically reviewed the literature, contributed to writing the manuscript, and critically revised the paper. All authors read and approved the final manuscript. KER and TEW are guarantors of the paper.

Competing interests
The authors declare that they have no competing interests.