Review of key Messages
Neuro-immune system interactions play a key role in CP.
IL-4/IL-13 signaling through the IL-4Ra receptor on peripheral sensory neurons and downstream Janus kinase-signal transducer of activation (JAK-STAT) pathway signaling lowers the threshold for itch.
Treatments targeting IL-31R, IL-4Ra, and intracellular JAK signaling for CP may in part induce clinical relief of itch through their action on peripheral sensory neurons.
Skin Therapy Letter. 2018;23(5):5-9. © 2018 SkinCareGuide.com