Chronic Pruritus: A Review of Neurophysiology and Associated Immune Neuromodulatory Treatments

Jay M. Patel, BSc; Harry Dao Jr., MD, FAAD


Skin Therapy Letter. 2018;23(5):5-9. 

In This Article

Review of key Messages

  • Neuro-immune system interactions play a key role in CP.

  • IL-4/IL-13 signaling through the IL-4Ra receptor on peripheral sensory neurons and downstream Janus kinase-signal transducer of activation (JAK-STAT) pathway signaling lowers the threshold for itch.

  • Treatments targeting IL-31R, IL-4Ra, and intracellular JAK signaling for CP may in part induce clinical relief of itch through their action on peripheral sensory neurons.