Uric Acid Control in Advanced Chronic Kidney Disease in a Southeastern US Urban Cohort

SD, standard deviation.

Glomerular filtration rate correlations at *P < 0.10, **P < 0.05, ***P < 0.01.
BMI, body mass index; GFR, glomerular filtration rate.

Excluded variables: age, sex, race, weight, potassium-wasting diuretics use, and race-adjusted glomerular filtration rate.
BMI, body mass index.

Authors and Disclosures

Tibor Fülöp, MD, PhD, Christian A. Koch, MD, PhD, MACE, Lindsey T. Norris, MD, BetzaidaRodríguez, MD, Tibor Szarvas, PhD, Zsolt Lengvárszky, PhD, Éva Csongrádi, MD, PhD and Mehul P. Dixit, MD

Medical Services, Ralph H. Johnson VA Medical Center, Charleston, the Department of Medicine III, Technical University of Dresden, Dresden, Germany, the Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Mississippi Medical Center, Jackson, the Department of Medicine, Division of Nephrology, University of Mississippi Medical Center, Jackson, the Department of Mathematics, Louisiana State University, Shreveport, the Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, and the Department of Pediatrics, Division of Pediatric Nephrology, University of Mississippi Medical Center, Jackson.

Correspondence to
Dr Tibor Fülöp, Department of Medicine, Division of Nephrology, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC. 29425–6290 E-mail: fulopt@musc.edu. To purchase a single copy of this article, visit sma.org/smj-home. To purchase larger reprint quantities, please contact Reprintsolutions@wolterskluwer.com.

Sidebar

Key Points

• Most subjects had insufficient uric acid control, despite a fair dose of allopurinol (192 ± 99 mg/day) used.

• Body mass index and allopurinol dose had an impact on uric acid levels, whereas estimated glomerular filtration rate did not.

• Most subjects had ongoing urinary acidification, despite acceptable serum bicarbonate control.

• Weight may be an underappreciated determinant of allopurinol requirement, even in patients with chronic kidney disease.