A Case Series of Five Patients With Pure or Mixed Gestational Epithelioid Trophoblastic Tumors and a Literature Review on Mixed Tumors

Ka Yu Tse, MRCOG; Keith Wan Hang Chiu, FRCR; Karen Kar Loen Chan, FRCOG; Mandy Man Yee Chu, MRCOG; Siew Fei Ngu, MRCOG; Annie Nga Yin Cheung, FRCPath; Hextan Yuen Sheung Ngan, FRCOG; Philip Pun Ching Ip, FRCPath


Am J Clin Pathol. 2018;150(4):318-332. 

In This Article

Materials and Methods

This was a retrospective study carried out in the Division of Gynaecology Oncology, Department of Obstetrics and Gynaecology, Queen Mary Hospital. Approval of the Institutional Review Board of the University of Hong Kong/Hospital Authority Hong Kong West Cluster was obtained (reference number UW 16–354). Patients with a diagnosis of ETT were identified from our departmental cancer registry and pathology database between 2000 and 2015, and their medical notes were retrieved. Two gynecological pathologists (P.P.C.I. and A.N.Y.C.) reviewed the histology slides.

All patients underwent a panel of investigation, including serum hCG immunoassay, ultrasound of the pelvis and liver, and chest X-rays, to ascertain the FIGO stage and WHO score.[11] CBC and tests for liver function, urea and electrolytes, and thyroid function were conducted, and blood group was also checked. Other radiologic examinations such as computed tomography (CT)[13] and magnetic resonance imaging (MRI) were performed only when necessary. After completion of treatment, all patients would undergo lifelong follow-up with serum hCG.