Minimal Effective Weight-based Dosing of Ondansetron to Reduce Hypotension in Cesarean Section Under Spinal Anesthesia

A Randomized Controlled Superiority Trial

Maliwan Oofuvong; Thitikan Kunapaisal; Orarat Karnjanawanichkul; Nussara Dilokrattanaphijit; Jaranya Leeratiwong


BMC Anesthesiol. 2018;18(105) 

In This Article


Ondansetron administered at a dose of 0.05 mg/kg or 0.1 mg/kg before spinal anesthesia was not effective in reducing the incidence of hypotension in pregnant women undergoing cesarean section. Higher weight-based dosing of ondansetron should be examined keeping the safety issues in mind.