Polymer-based Dental Filling Materials Placed During Pregnancy and Risk to the Foetus

Trine Lise Lundekvam Berge; Gunvor Bentung Lygre; Stein Atle Lie; Lars Björkman


BMC Oral Health. 2018;18(144) 

In This Article


Dentist consultation during pregnancy was reported by 33,727 women, and of these, 10,972 had white fillings placed (Figure 1). Detailed descriptive information regarding the characteristics of the participants is included in Table 1. Of the included pregnancies, 204 (0.2%) resulted in a stillbirth. The overall proportion of malformation was 4.8%, and the proportion of very preterm births and late preterm births was 0.6 and 3.8%, respectively (Table 2).

Compared to the reference group, there was no statistically significant increased risk for any adverse birth outcomes for participants who had consulted a dentist during pregnancy without having white fillings placed or for those who had white fillings placed (Table 3).

Separate analyses by gender showed that girls born to mothers who had white fillings placed during pregnancy had an increased risk of being small for gestational age (below the 10th percentile) compared to the reference group. The unadjusted OR was 1.14 (95% CI 1.01–1.28; p = 0.029) while after adjustment for potential confounders, the OR was reduced and not statistically significant (OR = 1.10, 95% CI 0.97–1.24; Table 3).

Boys born to mothers who received white fillings during pregnancy had a slightly increased risk of being born late preterm compared to the boys born in the reference group. The unadjusted OR was 1.16 (95% CI 1.01–1.34; p = 0.041), and the adjusted OR was 1.13 (95% CI 0.98–1.31; p = 0.082; Table 3).