Cardiovascular Disease in Systemic Lupus Erythematosus: An Update

Yudong Liu; Mariana J. Kaplan


Curr Opin Rheumatol. 2018;30(5):441-448. 

In This Article


A number of SLE-specific mechanisms, such as dysfunctional immune regulation and defective endothelial cell function and vascular repair, contribute to the premature atherosclerosis in SLE. The biological insights in appreciating those complex interplays have progressed significantly, but further understanding of the clinical relevance of targeting those factors in reducing SLE-related CVD is required. In addition, continued efforts to investigate other mechanisms that lead to accelerated CVD in SLE are needed to provide better molecular candidates for therapeutic targeting, and ultimately to improve the CV outcomes.