Antiepileptic Drugs in Critically Ill Patients

Salia Farrokh; Pouya Tahsili-Fahadan; Eva K. Ritzl; John J. Lewin III; Marek A. Mirski


Crit Care. 2018;22(153) 

In This Article

Drugs Lowering Seizure Threshold

Polypharmacy is common in the ICU and can contribute to adverse drug effects such as seizures by lowering the seizure threshold or via drug-drug interactions that may reduce the blood concentration of an AED the patient may already be receiving (see the next section). Antibiotics, psychotropic agents, and analgesics have been all associated with seizures[101,102] (Table 7).