Comparative Addition of Dexmedetomidine and Fentanyl to Intrathecal Bupivacaine in Orthopedic Procedure in Lower Limbs

Poupak Rahimzadeh; Seyed Hamid Reza Faiz; Farnad Imani; Pooya Derakhshan; Saeed Amniati

Disclosures

BMC Anesthesiol. 2018;18(62) 

In This Article

Results

Ninety patients were randomly allocated to three groups of 30 patients. There was no significant difference between the groups in baseline findings (Table 1).

Characteristics of block between the three groups are demonstrated in Table 2. There was significant differences between BD with BF and BN groups in regression to Bromage 0 (p < 0.001), two segmental regression (p < 0.001), sensory regression to S1 (p < 0.001), time to rescue analgesia (p < 0.001) and NRS 6 h after surgery (p < 0.001) and between BF and BN in regression to Bromage 0 (p = 0.004), sensory regression to S1 (p < 0.001), time to rescue analgesia (p < 0.001), two segmental regression (p < 0.001), and between BD and BF in the highest sensory level (p = 0.03), but there was no significantly difference between groups in onset of Bromage 3 (p > 0.05).

In all three groups, the highest sensory block occurred in T6 dermatome (Table 3). T5 dermatome was the second highest in BD and BF groups, but T7 dermatome was the second highest block in BN group.

Figures 2 and 3 demonstrate Error bars of systolic and diastolic blood pressure and heart rate changes between groups before spinal anesthesia till 60 min after in each and between groups. Serial changes in SBP, DBP and HR were significant in each group (p < 0.001); these changes and reduction in SBP (p = 0.006), DBP (p = 0.03) and HR (p = 0.002) in BF group were significantly higher than BD and BN groups.

Figure 2.

Error Bars of Systolic and diastolic blood pressure changes between groups before spinal anesthesia till 60 min after in between groups

Figure 3.

Error Bar of Heart rate changes between groups before spinal anesthesia till 60 min after in between groups

Nausea, vomiting and chilling were higher in BN group and hypotension and bradycardia were higher in BF group, but there were no significant differences between three groups regarding the treatment side effects (Table 4).

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