The First Case of Multiple Pulmonary Granulomas With Amyloid Deposition in a Dental Technician

A Rare Manifestation as an Occupational Lung Disease

Taizou Hirano; Tadahisa Numakura; Hiroshi Moriyama; Ryoko Saito; Yutaka Shishikura; Jun Shiihara; Hisatoshi Sugiura; Masakazu Ichinose


BMC Pulm Med. 2018;18(77) 

In This Article


Occupational and environmental lung diseases are a broad group of pulmonary disorders caused by the inhalation of harmful dusts, chemicals, or proteins[1] and are one of the health problems among dental workers receiving increasing interest.[2,3] Working with dental abrasives and polishing materials can result in chronic exposure to various harmful materials such as silica, alloys, and acrylic plastics.[2–5] Pneumoconiosis is a well-known pulmonary disease in dental workers.[2–5] Although various types of pneumoconioses have been reported,[2–6] to our knowledge, the development of pulmonary amyloidosis has not been reported. Here, we describe the first reported case of a dental worker who developed multiple granulomas with amyloid deposition in the lung, which may have resulted from long-term exposure to silica in the workplace.