Bronchiectasis: An Emerging Global Epidemic

Sanjay H. Chotirmall; James D. Chalmers


BMC Pulm Med. 2018;18(76) 

In This Article

Lung Transplantation

Lung transplantation is a viable therapeutic option in bronchiectasis and only a few publications have reported on this management strategy for end-stage disease. This issue includes two original articles, one assessing transplant outcomes and the other international practice. Birch et al. report the outcomes of lung transplantation over a period of more than two decades from a major European transplant referral centre.[25] The data show that lung transplantation for bronchiectasis is useful, associated with good lung function and importantly survival, which is comparable to other bilateral lung transplant recipients suffering from other causes of end-stage respiratory failure. Tissot and colleagues focused on the difficult issue of NTM infection in CF patients suitable for transplant listing and ascertaining current international practice.[26] NTM infection is complex, therapeutically challenging and associated with poorer disease outcome in CF however the suitability of such patients for lung transplantation is poorly characterized. Data in this issue illustrate that across international transplant centres a lack of standards exists, leading to variable practices. Therefore, an urgent need for better quality data to aid clinical decision making exists to inform equitable access to lung transplant for NTM-infected CF patients.

The once silent bronchiectasis epidemic continues to gain momentum. Its recent global resurgence necessitates dedicated research and sustained investment if we are to improve the clinical care delivered and our understanding of its pathogenesis. This special issue dedicated to bronchiectasis aims to reaffirm its growing profile through the varied collection of articles focusing on its clinical, microbiological and therapeutic aspects. The time has come to control the evolving bronchiectasis epidemic, and to do so requires a collective manifesto of using evidenced based research to deliver safe and effective therapy to suffering patients with this life-threatening disease.