Systematic Review With Meta-analysis

Association Between Acetaminophen and Nonsteroidal Anti–inflammatory Drugs (NSAIDs) and Risk of Crohn's Disease and Ulcerative Colitis Exacerbation

O. O. Moninuola; W. Milligan; P. Lochhead; H. Khalili


Aliment Pharmacol Ther. 2018;47(11):1428-1439. 

In This Article


Contrary to generally accepted belief, we did not find a consistent association between acetaminophen, NSAIDs, or COX–2 inhibitor use and risk of CD and UC exacerbation. Nevertheless, analysis limited to studies with low risk of bias showed a positive association between NSAIDs use and CD exacerbation but not UC. Our meta–analysis confirms the need for larger well–designed studies examining the relationship between acetaminophen and NSAIDs, and disease activity among patients with established IBD.