An Algorithmic Approach to the Management of Infantile Digital Fibromatosis

Review of Literature and a Case Report

Elizabeth H. Eypper, MD; Johnson C. Lee, MD; Ashley J. Tarasen, MD; Maxene H. Weinberg, BS; Oluwaseun A. Adetayo, MD


ePlasty. 2018;18(e19) 

In This Article


A direct excision of the lesions with Brunner-type incisions was performed under general anesthesia. The lesion was noted to abut and was adherent to the underlying dermis from which the extirpation was performed. The procedure was successful without complications. The patient is now 33 months of age, has no recurrence at 2 years postsurgery, and continues to be followed (Figure 1). Histological examination revealed a proliferation of bland, uniformly plump spindle cells with elongated nuclei and small central nucleoli without paranuclear inclusions (Figure 2). Variably admixed collagen was identified. Immunohistochemical studies showed the tumor cells to be positive for smooth muscle myosin, desmin, CD10, and calponin, consistent with fibromatosis.

Figure 1.

Postoperative photographs taken at 1 and 2 years follow-up. The (a) right and (b) left feet at 1 year follow-up. (c) Both feet at 2 years follow-up.

Figure 2.

Hematoxylin-eosin stain of tissue removed from the foot of a 9-month-old patient with infantile digital fibromatosis. Spindle cells demonstrate elongated nuclei with small central nucleoli. Paranuclear inclusions are not present.