Triptans and SSRIs: Is Serotonin Syndrome Really a Risk?

Douglas S. Paauw, MD


June 07, 2018

A 22-year-old college student, well known to you, presents with a complaint of worsening migraine headaches. She has a history of moderate depression that has been well controlled on citalopram 20 mg/day. She is otherwise healthy and on no other medications. After discussion, you elect to begin her on a trial of a triptan. Later that day, you receive a call from the pharmacist at her pharmacy to inform you that you are prescribing a triptan for a patient who is on a selective serotonin reuptake inhibitor (SSRI).


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