A Systematic Review of Intravaginal Testosterone for the Treatment of Vulvovaginal Atrophy

Robin J. Bell, MBBS, PhD, MPH, FAFPHM; Farwa Rizvi, MBBS, MPH; Rakabul M. Islam, MPH, PhD; Susan R. Davis, MBBS, PhD, FRACP


Menopause. 2018;25(6):704-709. 

In This Article


Although intravaginal therapy appears to be a promising treatment alternative for VVA, the available clinical trial data are insufficient to support this approach in clinical practice. Future double-blind, placebo-controlled clinical trials of intravaginal testosterone therapy need to include both objective clinical outcome measures and measurement of serum sex steroids by LCMS, and to be sufficiently powered, to establish both efficacy and safety.