Effects of Endogenous Sex Hormones on Lung Function and Symptom Control in Adolescents With Asthma

Mark D. DeBoer; Brenda R. Phillips; David T. Mauger; Joe Zein; Serpil C. Erzurum; Anne M. Fitzpatrick; Benjamin M. Gaston; Ross Myers; Kristie R. Ross; James Chmiel; Min Jie Lee; John V. Fahy; Michael Peters; Ngoc P. Ly; Sally E. Wenzel; Merritt L. Fajt; Fernando Holguin; Wendy C. Moore; Stephen P. Peters; Deborah Meyers; Eugene R. Bleecker; Mario Castro; Andrea M. Coverstone; Leonard B. Bacharier; Nizar N. Jarjour; Ronald L. Sorkness; Sima Ramratnam; Anne-Marie Irani; Elliot Israel; Bruce Levy; Wanda Phipatanakul; Jonathan M. Gaffin; W. Gerald Teague


BMC Pulm Med. 2018;18(58) 

In This Article


These results impact understanding of the differences in asthma features with pubertal maturation and the potential for new treatment. The androgen surge with puberty is likely to confer protective effects on lung growth in both males and females whereas estrogens may well have deleterious effects in females extending into adult development. A trial of weak androgen therapy in adolescent children with low androgen levels and poorly-controlled asthma could be considered to improve lung function. These data may help to explain the gender switch observed in asthma incidence during adolescence and likewise inform lung growth and asthma severity with subsequent maturation into adulthood.