Clinical Assessment of a Biofilm-Disrupting Agent for the Management of Chronic Wounds Compared With Standard of Care

A Therapeutic Approach

Daniel Kim, MD; William Namen II, DPM; January Moore, BA; Mauricia Buchanan, BSN; Valerie Hayes, PhD; Matthew F. Myntti, PhD; Albert Hakaim, MD


Wounds. 2018;30(5):120-130. 

In This Article


In summary, the results of this study confirm that the use of a biofilm-disrupting agent combined with debridement is more effective than the experimental antibiotic ointment combined with debridement or prior failed wound treatments. This reinforces previous results[8] obtained when combining this product with other ointments and debridement or with debridement alone. As the experimental agent specifically targets the biofilm by degrading the EPS, the results seen provide further confirmation that biofilm bacteria significantly contribute to the delay or arrest in the healing of chronic wounds. Given the significant wound healing and closure rates observed in these long-term, nonhealing wounds, as well as the lack of related serious adverse events, using the biofilm-disrupting wound gel appears to be safe and effective for the management of chronic wounds.