Top 20 Research Studies of 2017 for Primary Care Physicians

Mark H. Ebell, MD, MS; Roland Grad, MD, MSc,


Am Fam Physician. 2018;97(9):581-588. 

In This Article


Two studies are included as miscellaneous POEMs (Table 6).[29,30] Study 19 compared ibuprofen, naproxen, and celecoxib (Celebrex) and found no difference in cardiovascular events and only very small differences in gastrointestinal or renal events (less than 0.5%) among the three drugs.[29] The choice of drug should therefore be based on other factors, such as cost and patient preference, rather than the likelihood of adverse events. To round out the top 20 list, Study 20 is a systematic review of 10 randomized trials with 7,266 patients who had obstructive sleep apnea. There was no evidence that use of continuous positive airway pressure reduced the risk of cardiovascular events or death.[30] The decision to recommend continuous positive airway pressure should be based only on tolerability and effect on symptoms.