New Insights Into the Key Role of Interleukin 6 in Vascular Calcification of Chronic Kidney Disease

Lucie Hénaut; Ziad A. Massy


Nephrol Dial Transplant. 2018;33(4):543-548. 

In This Article

Abstract and Introduction


Cardiovascular disease is the leading cause of death in patients with chronic kidney disease (CKD). Low-grade systemic inflammation, which is frequently observed in such patients, is an independent risk factor for cardiovascular morbidity and mortality.[1] High circulating levels of inflammation markers are known to be associated with increased prevalence, severity and progression of vascular calcification[2] and in turn, vascular calcification also is associated with excess cardiovascular mortality in CKD. Experimental studies suggest that the nature of the association between low-grade systemic inflammation and vascular calcification is causal.[3] If confirmed in humans, this could have major therapeutic consequences. To date, the molecular mechanisms involved remain incompletely understood.