A 71-Year-Old Man With Malaise and Weight Loss: Osmosis USMLE Study Question 

June 26, 2020

Chronic lymphocytic leukemia (CLL) is the single most common subtype of leukemia overall and primarily affects adults older than 65 years. Men are twice as likely as women to develop CLL. Patients with CLL may be asymptomatic for some time but can also present with nonspecific symptoms, including weight loss, fatigue, lymphadenopathy, and splenomegaly. Clinical suspicion is confirmed using flow cytometry. The most common approach towards treatment is via palliative chemotherapy and often only initiated once symptoms are present.

Major Takeaway: CLL is the most common subtype of leukemia and is seen most often in men older than 65 years. The diagnosis is confirmed via flow cytometry, which reveals a lymphocytic predominance.

Read more on CLL.

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