Does Coenzyme Q10 Supplementation Mitigate Statin-Associated Muscle Symptoms?

Pharmacological and Methodological Considerations

Beth A. Taylor


Am J Cardiovasc Drugs. 2018;18(2):75-82. 

In This Article


SAMS are a major public health problem because they decrease medication compliance, ultimately increasing the likelihood of future preventable cardiovascular events in patients who warrant these life-saving medications. Effective strategies for treating SAMS are critically important, and CoQ10 supplementation is among the most popular. However, current cumulative clinical trials data do not support efficacy of CoQ10 for treating SAMS. Whether this is due to methodological and/or pharmacological considerations or a true lack of efficacy needs to be established in future clinical trials designed to close gaps in knowledge that previous trials have not yet addressed. Compliance with Ethical Standards