Many Breast Cancer Patients Not Receiving Genetic Evaluation

Roxanne Nelson, RN, BSN

March 14, 2018

A substantial number of breast cancer patients who could benefit from genetic testing are not being tested, and many others are not being counseled.

A new study shows that in a large cohort of more than 1700 early breast cancer patients, 47.4% were not tested. Although the majority of patients did report having some type of genetic discussion, only half of those who were not tested received any discussion about genetics.

The study was published online March 12 in the Journal of Clinical Oncology.

"Patients diagnosed with breast cancer need comprehensive patient-centered communication and decision making," said study author Steven J. Katz, MD, MPH, professor of general medicine and of health management and policy at the University of Michigan, Ann Arbor.

He explained that the "whole process needs to be slowed down, as too often its considered a medical emergency, especially by patients.

Dr Steven Katz

"Both patients and doctors need time to collect all the information, including genetic predisposition, in those at higher pretest risk of mutations," Katz told Medscape Medical News. "Doctors need to be better trained at counseling and integrating genetic counseling into treatment decisions. Treatment of cancer is largely focused on the biological subtype of the diagnosed cancer, while genetic predisposition plays a much smaller role in surviving cancer."

The authors note that genetic counseling is indicated for breast cancer patients who have an elevated pretest risk of harboring a pathogenic mutation. About one third of newly diagnosed patients do have a higher risk for a genetic mutation, as determined on the basis of their having a family history of cancer, their ancestry, and/or tumor characteristics.

But as testing is becoming more extensive, genetic risk evaluation — including counseling and genetic testing — is currently chaotically deployed into practice, Katz noted.

"Cost is not generally a problem, because the cost of testing is decreasing very quickly. The problem is the clinical utility of the testing today for patients with breast cancer, as there is legitimate clinical uncertainty about its role in treatment decision making," he said.

Testing and Counseling Uneven

Katz and his colleagues note that ideally, counseling should take place prior to surgery, because bilateral mastectomy is one of the options for risk reduction in this population. But putting genetic counseling into practice can be challenging, they note.

Information about integrating genetic counseling into community practices for newly diagnosed breast cancer patients is limited. In this study, they examined the patterns and correlates of discussion along with patient assessments about the information they received.

Surveys were sent to a large, diverse population of women aged 20 to 79 years with favorable-prognosis breast cancer who were identified from the SEER database of Georgia and Los Angeles County as having newly diagnosed ductal carcinoma in situ or invasive breast cancer. The surveys were linked to SEER clinical data and genetic test results. The cohort available for analysis included 1711 women with indications for formal genetic risk evaluation.

Of the women who were tested, 29.7% only received testing for BRCA1/2; 22.9% underwent a multigene panel test (representing 43.5% of those tested).

Of the patients who underwent testing, 14.0% received results indicating "variant of unknown significance (VUS)" only, and 8.6% were found to have a pathogenic mutation. The remainder (77.4%) received negative results.

Overall, nearly three quarters (74.6%) of the cohort received some type of genetic counseling: 43.5% received formal counseling, and 31.1% had a physician-directed discussion.

Genetic counseling was far less prevalent among those who were not tested. Only 22.6% received some type of formal counseling, and 28.0% had a physician-directed discussion. Conversely, almost all patients who were tested reported that they had received some form of genetic counseling (96.4% of those whose test results were negative, and 94.9% of those whose results indicated pathogenic mutations or VUS). About two thirds reported having received formal counseling (60.5% of those with negative test results, and 67.9% of those with pathogenic mutations or VUS).

Half of the women (n = 894) were asked about the timing of their visit with a genetic counselor relative to surgery. Of the 327 patients who had a formal genetic counseling session, 62.9% did so prior to undergoing surgery.

Information Received Was "Just Right"

With regard to patient assessment of the information received, the results were similar whether the information came from a genetic counselor or a physician: 80.8% of patients who received information from a genetic counselor reported that the information was "just right," vs 79.4% of those who received information from a physician (P = .58).

Among women who had any sort of discussion, Latino women were much less likely to report satisfaction with the information they received. Less than two thirds of Latino women (63.5%) considered the information to be "just right," as compared to 86.5% of white women, 75.6% of African Americans, and 80.3% of Asians (P < .001). More Latino women thought they had received too much information during these discussions, as compared to other groups (16.5% for Latino patients, vs 1.4% for whites, 6.5% for African Americans, and 4.1% for Asians; P < .001).

"We need to find new ways to better integrate genetic counseling into practice by incorporating different clinicians, including genetic counselors, more flexibly and giving them tools to help patients understand the implications of testing on their treatment," said senior study author Sarah T. Hawley, PhD, MPH, professor of internal medicine at Michigan Medicine, in a statement.

The study was funded by the National Cancer Institute. The authors have disclosed no relevant financial relationships.

J Clin Oncol. Published online March 12, 2018. Abstract


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