Treatment of Severe Skin and Soft Tissue Infections

A Review

Jason P. Burnham; Marin H. Kollef


Curr Opin Infect Dis. 2018;31(2):113-119. 

In This Article


SSTIs have a variety of presentations and can be severe enough to require intensive care. Practitioners should be familiar with the spectrum of clinical presentations for SSTI that require urgent surgical debridement to avoid delays in surgery as this can lead to worsened outcomes. Aggressive source control and broad spectrum antimicrobials are essential for all severe SSTI, with empiric therapy guided by knowledge of patient risk factors, the local antibiogram, and where available, rapid diagnostic testing.